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Home > Product > Recombinant proteins > Recombinant Ovine Interferon-tau protein

Recombinant Ovine Interferon-tau protein

Recombinant Ovine Interferon-tau protein

Product Summary

Size: 10 ug,2 ug

Purity: > 97 % by SDS-PAGE and HPLC analyses.

Source: Pichia Pastoris

Product Summary

Size: 10 ug,2 ug

Purity: > 97 % by SDS-PAGE and HPLC analyses.

Source: Pichia Pastoris

Product overview

Product name

Recombinant Ovine Interferon-tau protein

Code

CD00156

Biological activity

Fully biologically active when compared to IFN-alpha. The specific activity determined by a viral resistance assay is no less than 1.0 × 107 IU/mg.

Endotoxin

Less than 0.1 EU/μg of rOvIFN-τ as determined by LAL method.

Synonyms

IFN-τ, IFN-tau-c2, IFNT, IFNT1, TP-1,IFNT2,Ovine

Sequence

CYLSRKLMLD ARENLKLLDR MNRLSPHSCL QDRKDFGLPQ EMVEGDQLQK DQAFPVLYEM LQQSFNLFYT EHSSAAWDTT LLEQLCTGLQ QQLDHLDTCR GQVMGEEDSE LGNMDPIVTV KKYFQGIYDY LQEKGYSDCA WEIVRVEMMR ALTVSTTLQK RLTKMGGDLN SP

Uniprot Accession

Molecular Weight

Approximately 19.9 kDa, a single glycosylated polypeptide chain containing 172 amino acids.

Formulation

Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20°C. Further dilutions should be made in appropriate buffered solutions.

Background

IFN-τ is a new class of type I IFN that is secreted by the trophoblast and is the signal for maternal recognition of pregnancy in sheep. IFN-τ has potent immunosuppressive and antiviral activities similar to other type I IFN but is less cytotoxic than IFN-α/β. The current investigation concerns the effect of recombinant ovine IFN-tau (rOvIFN-τ) on the modulation of MHC class I and II expression on cloned mouse cerebrovascular endothelial (CVE) cells. IFN-tau induced tyrosine phosphorylation of Stat1 and up regulated the expression of MHC class I on CVE. One proposed action by which type I IFN reduce the relapse rate in MS is via interference with IFN-γ-induced MHC class II expression. IFN-τwas shown to down regulate IFN-γ-induced MHC class II expression on CVE and, hence, may be of potential therapeutic value in down regulating inflammation in the central nervous system (CNS). IFN-τdid not upregulate the expression of MHC class II on CVE. IFN-τalso inhibited the replication of Theilers virus in CVE.

Storage

-20ºC

Research area

Immunology

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Associated products

  • Size

    Code

    Price

  • 10 ug

    CD00156

    $409.00

  • 2 ug

    CD00156

    $176.00

Add to Cart

Lead time: Within two weeks

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