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Home > Product > Recombinant proteins > Recombinant Mouse IL-5 protein

Recombinant Mouse IL-5 protein

Recombinant Mouse IL-5 protein

Product Summary

Size: 5 ug

Purity: > 98 % by SDS-PAGE and HPLC analyses.

Source: Escherichia coli.

Product Summary

Size: 5 ug

Purity: > 98 % by SDS-PAGE and HPLC analyses.

Source: Escherichia coli.

Product overview

Product name

Recombinant Mouse IL-5 protein

Code

CD00354

Biological activity

Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 2 ng/ml, corresponding to a specific activity of > 5.0 × 105 IU/mg.

Endotoxin

Less than 0.1 EU/μg of rMuIL-5 as determined by LAL method.

Synonyms

IL-5,Il, Il5, Mouse

Sequence

MEIPMSTVVK ETLTQLSAHR ALLTSNETMR LPVPTHKNHQ LCIGEIFQGL DILKNQTVRG GTVEMLFQNL SLIKKYIDRQ KEKCGEERRR TRQFLDYLQE FLGVMSTEWA MEG

Uniprot Accession

Molecular Weight

Approximately 26.2 kDa, a disulfide-linked homodimeric protein containing two 113 amino acids.

Formulation

Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM Tris, pH 9.0, 150 mM NaCl.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 C. Further dilutions should be made in appropriate buffered solutions.

Background

IL-5, also named B-cell differentiation factor I, eosinophil differentiation factor and TRF, is belonging to the cytokine family and the IL-5 gene is in close proximity to the genes encoding IL-3, IL-4, and granulocyte-macrophage colony-stimulating factor (GM-CSF), which are often co-expressed in TH2 cells. Through binding to the IL-5 receptor, IL-5 stimulates B cell growth and increases immunroglobulin secretion. It is also a key mediator in eosinophil activation. Interleukin-5 has long been associated with the cause of several allergic diseases including allergic rhinitis and asthma. Mouse IL-5 is a 113-amino acid (115 in human, 113 in rat) -long TH2 cytokine that is part of the hematopoietic family. Unlike other members of this cytokine family (namely IL-3 and GM-CSF), this glycoprotein in its active form is a homodimer.

Storage

-20ºC

Research area

Immunology

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Associated products

  • Size

    Code

    Price

  • 5 ug

    CD00354

    $176.00

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Lead time: Within two weeks

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