Product name
Recombinant Mouse Eotaxin-2/CCL24 protein
Code
CD00473
Biological activity
Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using Mouse lymphocytes is in a concentration of 10-100 ng/ml.
Endotoxin
Less than 1 EU/μg of rMuEotaxin-2/CCL24 as determined by LAL method.
Synonyms
Eotaxin-2/CCL24, CKb-6, MPIF, MPIF-2, Scya, Scya24, eotax,Mouse
Sequence
VTIPSSCCTS FISKKIPENR VVSYQLANGS ICPKAGVIFI TKKGHKICTD PKLLWVQRHI QKLDAKKNQP SKGAKAVRTK FAVQRRRGNS TEV
Uniprot Accession
Molecular Weight
Approximately 10.3 kDa, a single, non-glycosylated polypeptide chain containing 93 amino acids.
Formulation
Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB, pH 7.4, 150 mM NaCl.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 C. Further dilutions should be made in appropriate buffered solutions.
Background
CCL24, also named MPIF-2, Eotaxin-2 and Ckβ6, is a novel CC chemokine recently identified. It is a secreted protein, encoded by CCL24 gene, and produced by activated monocytes and T lymphocytes. CCL24 signals through the CCR3 receptor and has functions of chemotactic activity for resting T-lymphocytes and eosinophils, but none for monocytes and activated lymphocytes. The plasma levels of CCL24 and the aspirin-exacerbated respiratory disease (such as asthma) morbidity rate have positive correlation.
Storage
-20ºC
Research area
Immunology
