Product name
Recombinant Mouse DCIP-1/CXCL3 protein
Code
CD00488
Biological activity
Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human CXCR2 transfected human 293 cells is in a concentration range of 10-100 ng/ml.
Endotoxin
Less than 1 EU/μg of rMuDCIP-1/CXCL3 as determined by LAL method.
Synonyms
DCIP-1/CXCL3, Dci; Dcip1; Gm1960,Mouse
Sequence
AVVASELRCQ CLNTLPRVDF ETIQSLTVTP PGPHCTQTEV IATLKDGQEV CLNPQGPRLQ IIIKKILKSG KSS
Uniprot Accession
Molecular Weight
Approximately 7.9 kDa, a single, non-glycosylated polypeptide chain containing 73 amino acids.
Formulation
Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 C. Further dilutions should be made in appropriate buffered solutions.
Background
CXCL3, also known as DCIP1 in Mouse, CINC2 in rat, and GROγ in humans, is belonging to the CXC chemokine family. It is encoded by the gene CXCL3 in mouse. The functional receptor for CXCL3 has been identified as CXCR2. Similar to other GRO proteins, CXCL3 is potent neutrophil attractants and activators. CXCL3 plays a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. The amino acid sequence of Mouse CXCL3 is 57 % identical to human CXCL3.
Storage
-20ºC
Research area
Immunology
