Product name
Recombinant Human Uteroglobin protein
Code
CD00701
Biological activity
Fully biologically active when compared to standard. The ED50 as determined by the ability of the immobilized protein to support the adhesion of the A549 human lung carcinoma cells is less than 5.0 μg/ml, corresponding to a specific activity of > 200 IU/mg.
Endotoxin
Less than 0.1 EU/μg of rHuUteroglobin as determined by LAL method.
Synonyms
Uteroglobin, Scgb1a1,CC10, CC16, CCPBP, CCSP, UGB, UP-1, UP1, Human
Sequence
EICPSFQRVI ETLLMDTPSS YEAAMELFSP DQDMREAGAQ LKKLVDTLPQ KPRESIIKLM EKIAQSSLCN
Uniprot Accession
Molecular Weight
Approximately 15.8 kDa, a disulfide-linked homodimeric protein containing two 70 amino acid residues polypeptide.
Formulation
Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
Background
Uteroglobin, a member of the Secretoglobin (SCGBs) superfamily, is a multifunctional protein that can exert anti-inflammatory and anti-tumorigenic effects by binding small hydrophobic molecules such as phospholipids and prostaglandins. It is expressed by Clara cells, the non-ciliated, non-mucous secretory cells predominant in lung bronchioles, and by other epithelia that communicate with the external environment. In addition to sequestering pro-inflammatory mediators and carcinogens, Uteroglobin has been implicated in the inhibition of cell migration and invasion, platelet aggregation, and T cell differentiation. Recombinant Human Uteroglobin is a 15.8 kDa homodimeric protein consisting of two 70 amino acid residues.
Storage
-20ºC
Research area
Others
