Product name
Recombinant Human Eotaxin-3/CCL26 protein
Code
CD01865
Biological activity
Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human CCR3 transfected HEK293 cells is in a concentration range of 0.5-2.0 μg/ml.
Endotoxin
Less than 1 EU/μg of rHuEotaxin-3/CCL26 as determined by LAL method.
Synonyms
Eotaxin-3/CCL26,IMAC; TSC-1; MIP-4a; SCYA26; MIP-4alpha, Human
Sequence
TRGSDISKTC CFQYSHKPLP WTWVRSYEFT SNSCSQRAVI FTTKRGKKVC THPRKKWVQK YISLLKTPKQ L
Uniprot Accession
Molecular Weight
Approximately 8.4 kDa, a single non-glycosylated polypeptide chain containing 71 amino acid residues.
Formulation
Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 C. Further dilutions should be made in appropriate buffered solutions.
Background
CCL26 is novel CC family chemokine, also known as TARC (thymus and activation regulated chemokine). It is encoded by CCL26 gene, which is located on Chr.7 in humans, and ubiquitously expressed at low levels in various tissues including heart and ovary. CCL26 elicits its effects activity by binding to the cell surface chemokine receptor CCR3, and chemotactic for eosinophils and basophils.
Storage
-20ºC
Research area
Immunology
