Product name
Recombinant Human BMP-4 protein
Code
CD02240
Biological activity
Data is not available.
Endotoxin
Less than 1 EU/μg of rHuBMP-4 as determined by LAL method.
Synonyms
BMP-4, BMP4,BMP2B, BMP2B1, MCOPS6, OFC11, ZYME,Human
Sequence
MSPKHHSQRA RKKNKNCRRH SLYVDFSDVG WNDWIVAPPG YQAFYCHGDC PFPLADHLNS TNHAIVQTLV NSVNSSIPKA CCVPTELSAI SMLYLDEYDK VVLKNYQEMV VEGCGCR
Uniprot Accession
Molecular Weight
Approximately 13.3 kDa, a monomeric, non-glycosylated polypeptide chain containing 117 amino acids.
Formulation
Lyophilized from a 0.2 μm filtered concentrated solution in 50 mM Na2CO3, 5 mM DTT, pH 11.0.
Reconstitution
1. Molecular standard (Western, ELISA) in studying secreted BMP-4; 2. Preparing antibodies for BMP-4 monomer; 3. Molecule standard in detecting secreted BMP-4 in reduced SDS-PAGE.
Background
Bone Morphogenetic Protein 4 is one of the BMPs, some of which belong to the TGF-beta superfamily (BMP2-7). There are more than thirteen BMPs have been discovered nowadays and they are involved in inducing cartilage and bone formation. BMP-4 is expressed in the lung and lower levels seen in the kidney. It also presents in normal and neoplastic prostate tissues, and prostate cancer cell lines. It regulates the formation of teeth, limbs and bone from mesoderm. Furthermore it also plays a role in fracture repair. BMP-4 signals through tetrameric complexes composed of type I and type II receptors and regulates it function by interaction with multiple proteins and glycosaminoglycans. The human BMP-4 shares 98 % sequence indentity with mouse BMP-4. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva.
Storage
-20ºC
Research area
Immunology
