Product name
Recombinant Human AITR Ligand/TNFSF18 protein
Code
CD02368
Biological activity
Fully biologically active when compared to standard. The biological activity as determined by stimulation of IL-8 production using human PBMC is in a concentration range of 0.1-10 ng/ml.
Endotoxin
Less than 0.1 EU/μg of rHuAITR Ligand/TNFSF18 as determined by LAL method.
Synonyms
AITR Ligand/TNFSF18, AITR, CD357, ENERGEN, GITR, GITR-D,Human
Sequence
ETAKEPCMAK FGPLPSKWQM ASSEPPCVNK VSDWKLEILQ NGLYLIYGQV APNANYNDVA PFEVRLYKNK DMIQTLTNKS KIQNVGGTYE LHVGDTIDLI FNSEHQVLKN NTYWGIILLA NPQFIS
Uniprot Accession
Molecular Weight
Approximately 14.3 kDa, a single non-glycosylated polypeptide chain containing 126 amino acids.
Formulation
Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH7.4.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 C. Further dilutions should be made in appropriate buffered solutions.
Background
AITR Ligand (activation-inducible TNF receptor superfamily member ligand) is also named GITR Ligand (glucocorticoid-induced tumor necrosis factor receptor ligand) and TNFRSF18, regulates T-cell proliferation and survival, and effectuates the interaction between T lymphocytes and endothelial cells. The AITRL gene codes for a type II transmembrane protein comprised of 177 amino acids, including a 28 amino acid cytoplasmic region, a 21 amino acid transmembrane domain and a 128 amino acid extracellular domain. Recombinant human AITRL is a 14.3 kDa protein, containing 126 amino acid residues corresponding to the extracellular domain of AITR Ligand.
Storage
-20ºC
Research area
Others
