TTR mouse Monoclonal Antibody(1D7)

Product overview

Full product name

Transthyretin

Code

BT-MCA0077

Host

Mouse

Isotype

IgG

Size

20ul,50ul,100ul

Clonality

Monoclonal

Immunogen

Recombinant Protein of TTR

Purification

The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

-20°C for one year

Background

This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein| it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported| most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.

Uniprot accession

Human:;Mouse:;

Molecular weight

N/A

Gene ID

Human: 7276

Synonyms

Transthyretin; ATTR; Prealbumin; TBPA

Research area

Cardiovascular; Neuroscience

Target protein

TTR PALB

Recommended dilution

Application	Dilution
IF	1:50-200
IHC-p	1:50-300
WB	1:500-2000

Images

Immunofluorescence analysis of human-liver-cancer tissue. 1.TTR Mouse Monoclonal antibody(1D7)(red) was diluted at 1:200(4°C,overnight). 2. Cy3 labled Secondary antibody was diluted at 1:300(room temperature, 50min).3. Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B

Immunohistochemical analysis of paraffin-embedded Human-lung tissue. 1.TTR Mouse Monoclonal antibody(1D7) was diluted at 1:200(4°C,overnight). 2.Sodium citrate pH 6.0 was used for antibody retrieval(>98°C,20min). 3.Secondary antibody was diluted at 1:200(room temperature, 30min). Negative control was used by secondary antibody only.

Immunohistochemical analysis of paraffin-embedded Human Liver Carcinoma Tissue using TTR Mouse Monoclonal antibody diluted at 1:200

Immunohistochemical analysis of paraffin-embedded Human Thyroid Tissue using TTR Mouse Monoclonal antibody diluted at 1:200

Western blot analysis of Human Serum using TTR Mouse Monoclonal antibody diluted at 1:2000.

Immunohistochemical analysis of paraffin-embedded Human colon.1.Antibody was diluted at 1:200(4°C overnight). 2.High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3.Secondary antibody was diluted at 1:200(room temperature, 30min).

Immunohistochemical analysis of paraffin-embedded Human stomach.1.Antibody was diluted at 1:200(4°C overnight). 2.High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3.Secondary antibody was diluted at 1:200(room temperature, 30min).

Protocols

> Protocol Booklet

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