Product overview
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Immunogen
Purification
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Background
This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene.
Uniprot accession
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Target protein
Recommended dilution
| Application | Dilution |
|---|---|
| FC | 1:200 - 1:400 |
| IF | 1:200 - 1:1000 |
| IHC | 1:200 - 1:1000 |
| WB | 1:500 - 1:2000 |
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