Product overview
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Immunogen
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Background
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene.
Uniprot accession
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Target protein
Recommended dilution
Application | Dilution |
---|---|
ELISA | 1:10000 |
WB | 1:500 - 1:2000 |
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