Product overview
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Host
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Immunogen
Purification
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Background
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
Uniprot accession
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Gene ID
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Target protein
Recommended dilution
| Application | Dilution |
|---|---|
| FC | 1:200 - 1:400 |
| IF | 1:200 - 1:1000 |
| IHC | 1:200 - 1:1000 |
| WB | 1:500 - 1:2000 |
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