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Background
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.
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Target protein
Recommended dilution
| Application | Dilution |
|---|---|
| IF | 1:100 - 1:500 |
| IHC | 1:500 - 1:1000 |
| WB | 1:1000 - 1:2000 |
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