ASK1

BT-AP06120

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized phosho peptide around human ASK1 (Thr845)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK)| MAPK kinase (MKK or MEK)| and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase| MAPK kinase/MEK| which in turn activates MAPK. The kinases of these signaling cascades are highly conserved| and homologs exist in yeast| Drosophila| and mammalian cells. MAPKKK5 contains 1|374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1| MAPKK4) in vitro| and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.

Human:;Mouse:;

Human: 4217; Mouse: 26408

ASK1 ;Thr845; Mitogen-activated protein kinase kinase kinase 5; EC 2.7.11.25; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5

Cardiovascular; Cell biology

MAP3K5