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Home > Product > Antibody > ErbB-3(Phospho Tyr1289) Polyclonal Antibody

ErbB-3(Phospho Tyr1289) Polyclonal Antibody

ErbB-3(Phospho Tyr1289) Polyclonal Antibody

Product Summary

Size: 100ul,50ul,20ul

Clonality: Polyclonal

Host: Rabbit

Reactivity:Human, Mouse, Rat

Applications: WB, IHC-p, IF, ICC, ELISA

Product Summary

Size: 100ul,50ul,20ul

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC-p, IF, ICC, ELISA

Product overview

Full product name

Receptor tyrosine-protein kinase erbB-3

Code

BT-AP00615

Host

Rabbit

Isotype

IgG

Size

100ul,50ul,20ul

Clonality

Polyclonal

Immunogen

The antiserum was produced against synthesized peptide derived from human HER3 around the phosphorylation site of Tyr1289. AA range:1256-1305

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

-20°C for 1 year

Background

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the m

Uniprot accession

Molecular weight

148098

Gene ID

Human: 2065; Mouse: 13867; Rat: 29496

Synonyms

Receptor tyrosine-protein kinase erbB-3; ERBB3; HER3; Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3

Research area

Cancer; Cell biology; Developmental biology; Signal transduction; Tags & cell markers

Target protein

ERBB3

Recommended dilution

Application Dilution
WB 1: 500 - 1: 2000
IHC-p 1: 100 - 1: 300
IF 1: 200 - 1: 1000
ICC 1: 200 - 1: 1000
ELISA 1: 10000

Images

Immunofluorescence analysis of HeLa cells, using HER3 (Phospho-Tyr1289) Antibody. The picture on the right is blocked with the phospho peptide.
Western Blot analysis of Hela cells using Phospho-ErbB-3 (Y1289) Polyclonal Antibody diluted at 1:1000
Western blot analysis of HER3 (Phospho-Tyr1289) Antibody. The lane on the right is blocked with the HER3 (Phospho-Tyr1289) peptide.

Protocols

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Product size

Price

  • 100ul

    $275.00

  • 50ul

    $180.00

  • 20ul

    $108.00

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Lead time: Within one week

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