FADD(Phospho Ser191) Polyclonal Antibody

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Blood coagulation
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Home > Product > Antibody > FADD(Phospho Ser191) Polyclonal Antibody

FADD(Phospho Ser191) Polyclonal Antibody

Product Summary

Size: 100ul,50ul,20ul

Clonality: Polyclonal

Host: Rabbit

Reactivity:Mouse

Applications: WB, IHC-p, IF, ELISA

Product Summary

Size: 100ul,50ul,20ul

Clonality: Polyclonal

Host: Rabbit

Reactivity: Mouse

Applications: WB, IHC-p, IF, ELISA

Product overview

Full product name

Protein FADD

Code

BT-AP06166

Host

Rabbit

Isotype

IgG

Size

100ul,50ul,20ul

Clonality

Polyclonal

Immunogen

The antiserum was produced against synthesized peptide derived from mouse FADD around the phosphorylation site of Ser191. AA range:157-206

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

-20°C for 1 year

Background

The Fas associated via death domain encoded by FADD is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

Molecular weight

23279

Gene ID

Mouse: 14082

Synonyms

Protein FADD; FADD; MORT1; GIG3; Protein FADD; FAS-associated death domain protein; FAS-associating death domain-containing protein; Growth-inhibiting gene 3 protein; Mediator of receptor induced toxicity

Research area

Cancer; Cell biology

Target protein

FADD

Recommended dilution

Application	Dilution
WB	1: 500 - 1: 2000
IHC-p	1: 100 - 1: 300
ELISA	1: 5000

Images

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using FADD (Phospho-Ser191) Antibody. The picture on the right is blocked with the phospho peptide.

Western Blot analysis of JK cells using Phospho-FADD (S191) Polyclonal Antibody

Western blot analysis of lysates from Jurkat cells treated with PMA 125ng/ml 30', using FADD (Phospho-Ser191) Antibody. The lane on the right is blocked with the phospho peptide.

Protocols

> Protocol Booklet

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Datasheet

Product size

Price

100ul

$275.00
50ul

$180.00
20ul

$108.00

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Lead time: Within one week

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