BMPR-II

BT-AP06581

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized peptide derived from human BMPR-II

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs| which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors| but they require their respective type I receptors for signaling| whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension| both familial and fenfluramine-associated| and with pulmonary venoocclusive disea

Human:;Mouse:;

114180

Human: 659; Mouse: 12168

BMPR-II; Bone morphogenetic protein receptor type-2; BMP type-2 receptor; BMPR-2; EC 2.7.11.30; Bone morphogenetic protein receptor type II; BMP type II receptor; BMPR-II

Cardiovascular; Signal transduction; Stem cells

BMPR2