IDHP

BT-AP00944

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized peptide derived from human IDHP

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses| one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases| which localize to the mitochondrial matrix| and two NADP(+)-dependent isocitrate dehydrogenases| one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants.

Human:;

Human: 3418

IDHP; Isocitrate dehydrogenase [NADP; ; mitochondrial; IDH; EC 1.1.1.42; ICD-M; IDP; NADP;+-specific ICDH; Oxalosuccinate decarboxylase

Cancer; Metabolism; Signal transduction

IDH2