Collagen XVIII alpha 1

BT-AP08259

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized peptide derived from human Collagen XVIII α1 (Cleaved-His1572)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins| extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin| a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities| so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants.

Human:;Mouse:;

192940

Human: 80781; Mouse: 12822

Collagen XVIII α1 ;Cleaved-His1572; Collagen alpha-1;XVIII chain [Cleaved into: Endostatin;

Cancer; Cardiovascular; Signal transduction

COL18A1