IGF-IR(Phospho Tyr1161) Polyclonal Antibody

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Blood coagulation
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Home > Product > Antibody > IGF-IR(Phospho Tyr1161) Polyclonal Antibody

IGF-IR(Phospho Tyr1161) Polyclonal Antibody

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity:Human, Mouse, Rat

Applications: WB, IHC-p, IF, IP, ELISA

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC-p, IF, IP, ELISA

Product overview

Full product name

Insulin-like growth factor 1 receptor

Code

BT-AP08809

Host

Rabbit

Isotype

IgG

Size

20ul,50ul,100ul

Clonality

Polyclonal

Immunogen

The antiserum was produced against synthesized peptide derived from human IGF1R around the phosphorylation site of Tyr1161. AA range:1131-1180

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

-20°C for 1 year

Background

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Uniprot accession

Human:;Rat:;

Molecular weight

154793

Gene ID

Human: 3480/3643; Mouse: 16001/16337; Rat: 25718

Synonyms

Insulin-like growth factor 1 receptor; IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221; INSR; Insulin receptor; IR; CD antigen CD220

Research area

Signal transduction; Cancer; Developmental biology

Target protein

IGF1R

Recommended dilution

Application	Dilution
WB	1: 500 - 1: 2000
IP	2 - 5 ug: mg
IHC-p	1: 100 - 1: 300
ELISA	1: 20000

Images

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using IGF1R (Phospho-Tyr1161) Antibody. The picture on the right is blocked with the phospho peptide.

Western Blot analysis of various cells using Phospho-IGF-IR (Y1161) Polyclonal Antibody diluted at 1:2000

Western Blot analysis of 293 cells using Phospho-IGF-IR (Y1161) Polyclonal Antibody diluted at 1:2000

Western blot analysis of lysates from 293 cells treated with Insulin, using IGF1R (Phospho-Tyr1161) Antibody. The lane on the left is blocked with the phospho peptide.

Protocols

> Protocol Booklet

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Datasheet

Product size

Price

20ul

$108.00
50ul

$180.00
100ul

$275.00

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Lead time: Within one week

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