Doublecortin

BT-AP09322

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthesized phosho peptide around human Doublecortin (Ser297)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains| which bind microtubules. In the developing cortex| cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition| the encoded protein interacts with LIS1| the regulatory gamma subunit of platelet activating factor acetylhydrolase| and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex| leading to epilepsy| mental retardation| subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain&quo

Human:;Mouse:;Rat:;

Human: 1641; Mouse: 13193

Doublecortin (Ser297); Neuronal migration protein doublecortin; Doublin; Lissencephalin-X; Lis-X)

Neuroscience; Tags & cell markers

DCX