FBX32

BT-AP02650

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthesized peptide derived from human FBX32

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.66% sodium azide.

-20°C for 1 year

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif| the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box)| which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains| Fbls containing leucine-rich repeats| and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy| whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.

Human:;Mouse:;Rat:;

Human: 114907; Mouse: 67731; Rat: 171043

FBX32; F-box only protein 32; Atrogin-1; Muscle atrophy F-box protein; MAFbx)

Cardiovascular; Cell biology; Stem cells

FBXO32