FGD4

BT-AP10033

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthesized peptide derived from human FGD4

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.315% sodium azide.

-20°C for 1 year

This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain| which together with its Dbl homology domain and one of its pleckstrin homology domains| can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain| and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum| an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H)| a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Human:;Mouse:;Rat:;

Human: 121512; Mouse: 224014; Rat: 246174

FGD4; FYVE; RhoGEF and PH domain-containing protein 4; Actin filament-binding protein frabin; FGD1-related F-actin-binding protein; Zinc finger FYVE domain-containing protein 6)

Signal transduction

FGD4