GIT2

BT-AP10180

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized phosho peptide around human GIT2 (Tyr392)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

This gene encodes a member of the GIT protein family| which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes| focal adhesions| and the cell periphery| and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover| and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms| but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences| with respect to ARF GAP activity and to G

Human:;Mouse:;

Human: 9815; Mouse: 26431

GIT2 ;Tyr392 ; ARF GTPase-activating protein GIT2; ARF GAP GIT2; Cool-interacting tyrosine-phosphorylated protein 2; CAT-2; CAT2; G protein-coupled receptor kinase-interactor 2; GRK-interacting protein 2

Signal transduction

GIT2