MBD2 Rabbit Polyclonal Antibody

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Home > Product > Antibody > MBD2 Rabbit Polyclonal Antibody

MBD2 Rabbit Polyclonal Antibody

Product Summary

Size: 100ul,50ul,20ul

Clonality: Polyclonal

Host: Rabbit

Reactivity:Human, Mouse

Applications: WB

Product Summary

Size: 100ul,50ul,20ul

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB

Product overview

Full product name

MBD2

Code

BT-AP03548

Host

Rabbit

Isotype

IgG

Size

100ul,50ul,20ul

Clonality

Polyclonal

Immunogen

Synthesized peptide derived from human MBD2

Purification

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration

1 mg/ml

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

-20°C for 1 year

Background

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2| MBD1| MBD2| MBD3| and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins| with the exception of MBD3| is capable of binding specifically to methylated DNA. MECP2| MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription| as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.

Uniprot accession

Human:;Mouse:;

Molecular weight

45210

Gene ID

Human: 8932; Mouse: 17191

Synonyms

MBD2

Research area

Epigenetics and nuclear signaling

Target protein

MBD2

Recommended dilution

Application	Dilution
WB	1: 500 - 1: 2000

Images

Western blot analysis of lysates from SH-SY5Y cells, primary antibody was diluted at 1:1000, 4°C overnight

Protocols

> Protocol Booklet

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Datasheet

Product size

Price

100ul

$275.00
50ul

$180.00
20ul

$108.00

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Lead time: Within one week

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