MLCK

BT-AP03624

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized peptide derived from human MLCK (Phospho Tyr471)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

This gene| a muscle member of the immunoglobulin gene superfamily| encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition| using a separate promoter in an intron in the 3' region| it encodes telokin| a small protein identical in sequence to the C-terminus of myosin light chain kinase| that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been

Human:;Mouse:;

210540

Human: 4638; Mouse: 0

MLCK ;Phospho Tyr471; Myosin light chain kinase; smooth muscle; MLCK; smMLCK; EC 2.7.11.18; Kinase-related protein; KRP; Telokin; Myosin light chain kinase; smooth muscle; deglutamylated form;

Signal transduction

MYLK