NOTCH4

BT-AP03845

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized peptide derived from human NOTCH4 (Cleaved-Val1467)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats| and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular| renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants| at least one of which

Human:;Mouse:;

220330

Human: 4855; Mouse: 18132

NOTCH4 ;Cleaved-Val1467; Neurogenic locus notch homolog protein 4; Notch 4; hNotch4; Notch 4 extracellular truncation; Notch 4 intracellular domain;

Cardiovascular; Epigenetics and nuclear signaling; Stem cells

NOTCH4