NPC1 Rabbit Polyclonal Antibody

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Blood coagulation
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Home > Product > Antibody > NPC1 Rabbit Polyclonal Antibody

NPC1 Rabbit Polyclonal Antibody

Product Summary

Size: 100ul,50ul,20ul

Clonality: Polyclonal

Host: Rabbit

Reactivity:Human, Mouse

Applications: WB

Product Summary

Size: 100ul,50ul,20ul

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB

Product overview

Full product name

NPC1

Code

BT-AP11562

Host

Rabbit

Isotype

IgG

Size

100ul,50ul,20ul

Clonality

Polyclonal

Immunogen

Synthesized peptide derived from human NPC1

Purification

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration

1 mg/ml

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

-20°C for 1 year

Background

This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus| 13 transmembrane domains| and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease| a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.

Uniprot accession

Human:;Mouse:;

Molecular weight

140580

Gene ID

Human: 4864

Synonyms

NPC1

Research area

Cardiovascular; Metabolism; Neuroscience; Signal transduction

Target protein

NPC1

Recommended dilution

Application	Dilution
WB	1: 500 - 1: 2000

Images

Western blot analysis of lysates from KB cells, primary antibody was diluted at 1:1000, 4°C overnight

Protocols

> Protocol Booklet

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Datasheet

Product size

Price

100ul

$275.00
50ul

$180.00
20ul

$108.00

Add to Cart

Lead time: Within one week

Custom quote | Bulk request

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