PKA C

BT-AP11958

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized phosho peptide around human PKA C (Thr197)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

This gene encodes one of the catalytic subunits of protein kinase A| which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits| in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes| including differentiation| proliferation| and apoptosis. Constitutive activation of this gene caused either by somatic mutations| or genomic duplications of regions that include this gene| have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Altern

Human:;Mouse:;Rat:;

Human: 5566; Mouse: 18747

PKA C ;Thr197 ; cAMP-dependent protein kinase catalytic subunit alpha; PKA C-alpha; EC 2.7.11.11

Cancer; Cardiovascular; Signal transduction

PRKACA