PKC alpha/beta II

BT-AP11959

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized phosho peptide around human PKCα (Thr638 and 641)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters| a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes| such as cell adhesion| cell transformation| cell cycle checkpoint| and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.

Human: P17252; Mouse: P20444; Rat: P05696;

Human: 5578; Mouse: 18750

PKCα/β II ;Thr638/641; Protein kinase C alpha type; PKC-A; PKC-alpha; EC 2.7.11.13

Signal transduction; Cardiovascular; Cancer