PSMD1

BT-AP04318

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthesized peptide derived from human PSMD1

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.225% sodium azide.

-20°C for 1 year

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes| a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base| which contains 6 ATPase subunits and 2 non-ATPase subunits| and a lid| which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome| the immunoproteasome| is the processing of class I MHC peptides. This gene encodes the largest non-ATPase subunit of the 19S regulator lid| which is responsible for substrate recognition and binding. Alternatively spliced transcript variants have been found for this gene.

Human:;Mouse:;Rat:;

Human: 5707; Mouse: 70247; Rat: 83806

PSMD1; 26S proteasome non-ATPase regulatory subunit 1; 26S proteasome regulatory subunit RPN2; 26S proteasome regulatory subunit S1; 26S proteasome subunit p112

Cell biology; Signal transduction

PSMD1