Shc(Phospho-Tyr317) Rabbit Polyclonal Antibody

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Home > Product > Antibody > Shc(Phospho-Tyr317) Rabbit Polyclonal Antibody

Shc(Phospho-Tyr317) Rabbit Polyclonal Antibody

Product Summary

Size: 100ul,50ul,20ul

Clonality: Polyclonal

Host: Rabbit

Reactivity:Human, Mouse

Applications: WB

Product Summary

Size: 100ul,50ul,20ul

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB

Product overview

Full product name

Shc

Code

BT-AP04727

Host

Rabbit

Isotype

IgG

Size

100ul,50ul,20ul

Clonality

Polyclonal

Immunogen

Synthesized phosho peptide around human Shc (Tyr317)

Purification

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration

1 mg/ml

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

-20°C for 1 year

Background

This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways| the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms| p52Shc and p46Shc| link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms| p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.

Uniprot accession

Human:;Mouse:;Rat:;

Gene ID

Human: 6464; Mouse: 20416; Rat: 85385

Synonyms

Shc ;Tyr317; SHC-transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1; SH2 domain protein C1

Research area

Neuroscience; Signal transduction

Target protein

SHC1

Recommended dilution

Application	Dilution
WB	1: 1000 - 1: 2000

Protocols

> Protocol Booklet

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Datasheet

Product size

Price

100ul

$275.00
50ul

$180.00
20ul

$108.00

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Lead time: Within one week

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