Stat2

BT-AP12834

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized peptide derived from human Stat2 (Acetyl Lys384)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors| Jak kinases (TYK2 and JAK1) are activated| leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize| associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor| that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes| which drive the cell in an antiviral state.|PTM:Tyrosine phosphorylated in response to IFN-alpha.|Belongs to the transcription factor STAT family.|Contains 1 SH2 domain.|subcellular location:Translocated into the nucleus upon activation by IFN-alpha/beta.|subunit:Interacts with ISGF3G/IRF-9 in the cytoplasm. Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation. Interacts with CRSP2 and CRSP6. Interacts with Simian virus 5 protein V and rabies virus phosphoprotein.|

Human:;Mouse:;

93610

Human: 6773; Mouse: 0

Stat2 ;Acetyl Lys384; Signal transducer and activator of transcription 2; p113

Epigenetics and nuclear signaling; Signal transduction; Microbiology

STAT2