Stat5

BT-AP12838

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized phosho peptide around human Stat5 (Tyr694)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors| STAT family members are phosphorylated by the receptor associated kinases| and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands| such as IL2| IL4| CSF1| and different growth hormones. It has been shown to be involved in diverse biological processes| such as TCR signaling| apoptosis| adult mammary gland development| and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

Human:;Mouse:;Rat:;

Human: 6777; Mouse: 20851; Rat: 25126

Stat5 ;Tyr694; Signal transducer and activator of transcription 5B

Epigenetics and nuclear signaling; Cancer; Signal transduction; Metabolism

STAT5B