STRAB

BT-AP12887

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthesized peptide derived from human STRAB

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered| and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11| a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm| and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein| and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes| located on chromosomes 1 and 7| have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Human:;Mouse:;

45980

Human: 55437; Mouse: 227154

STRAB

Signal transduction; Metabolism; Cell biology

STRADB