Full product name
A disintegrin and metalloproteinase with thrombospondin motifs 5
Code
BT-AP06602
Host
Rabbit
Isotype
IgG
Size
100ul,50ul,20ul
Clonality
Polyclonal
Immunogen
Synthesized peptide derived from part region of human protein
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Storage
-20°C for 1 year
Background
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis.
Uniprot accession
Gene ID
Human: 11096
Synonyms
A disintegrin and metalloproteinase with thrombospondin motifs 5 ;ADAM-TS 5;ADAM-TS5;ADAMTS-5;EC 3.4.24.-;A disintegrin and metalloproteinase with thrombospondin motifs 11;ADAM-TS 11;ADAMT
Research area
Signal transduction; Cell biology
Target protein
ADAMTS5