Full product name
ICOS ligand
Code
BT-AP07353
Host
Rabbit
Isotype
IgG
Size
20ul,50ul,100ul
Clonality
Polyclonal
Immunogen
Synthetic peptide from human protein at AA range: 201-250
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage
-20°C for 1 year
Background
alternative products:Additional isoforms seem to exist,Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.,induction:Constitutive expression is further enhanced by treatment with TNF-alpha in peripheral blood B-cells and monocytes, while it is decreased in dendritic cells.,sequence The sequence differs from that shown in position 300 onward for unknown reason.,sequence Translation N-terminally shortened.,Belongs to the immunoglobulin superfamily. BTN/MOG family.,Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,Contains 1 Ig-like V-type (immunoglobulin-like) domain.,tissue specificity:Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.,
Uniprot accession
Gene ID
Human: 23308; Mouse: 50723
Synonyms
ICOS ligand ;B7 homolog 2;B7-H2;B7-like protein Gl50;B7-related protein 1;B7RP-1;CD antigen CD275; ICOS ligand; B7 homolog 2; B7-H2; B7-like protein Gl50; B7-related protein 1; B7RP-1; CD antigen CD275
Research area
Immunology
Target protein
ICOSLG
