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Home > Product > Antibody > Cdk6 Polyclonal Antibody

Cdk6 Polyclonal Antibody

Cdk6 Polyclonal Antibody

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity:Human, Rat, Mouse

Applications: WB, IHC-p, IF, ELISA

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Rat, Mouse

Applications: WB, IHC-p, IF, ELISA

Product overview

Full product name

Cyclin-dependent kinase 6

Code

BT-AP14883

Host

Rabbit

Isotype

IgG

Size

20ul,50ul,100ul

Clonality

Polyclonal

Immunogen

Synthetic peptide from human protein at AA range: 280-325

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

-20°C for 1 year

Background

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Uniprot accession

Gene ID

Human: 1021; Mouse: 12571

Synonyms

Cyclin-dependent kinase 6 ;EC 2.7.11.22;Cell division protein kinase 6;Serine/threonine-protein kinase PLSTIRE; Cyclin-dependent kinase 6; EC 2.7.11.22; Cell division protein kinase 6; Serine/threonine-protein kinase PLSTIRE

Research area

Cancer; Cell biology; Epigenetics and nuclear signaling

Target protein

CDK6

Recommended dilution

Application Dilution
WB 1: 500 - 1: 2000
IHC-p 1: 500 - 1: 200
ELISA 1: 20000
ELISA 1: 10000 - 1: 20000

Images

Immunohistochemical analysis of paraffin-embedded human-tonsil, antibody was diluted at 1:200
Immunohistochemical analysis of paraffin-embedded human-tonsil, antibody was diluted at 1:200
Immunohistochemical analysis of paraffin-embedded human-colon-cancer, antibody was diluted at 1:200
Immunohistochemical analysis of paraffin-embedded human-colon-cancer, antibody was diluted at 1:200
Western blot analysis of 293T Hela lysate, antibody was diluted at 2000. Secondary antibody was diluted at 1:20000

Protocols

Customer reviews and Q&As

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Product size

Price

  • 20ul

    $108.00

  • 50ul

    $180.00

  • 100ul

    $275.00

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Lead time: Within one week

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