Full product name
Estradiol 17-beta-dehydrogenase 1
Code
BT-AP15226
Host
Rabbit
Isotype
IgG
Size
20ul,50ul,100ul
Clonality
Polyclonal
Immunogen
Synthesized peptide derived from part region of human protein
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Storage
-20°C for 1 year
Background
This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has
Uniprot accession
Gene ID
Human: 3292
Synonyms
Estradiol 17-beta-dehydrogenase 1 ;EC 1.1.1.62;17-beta-hydroxysteroid dehydrogenase type 1;17-beta-HSD 1;20 alpha-hydroxysteroid dehydrogenase;20-alpha-HSD;E2DH;Placental 17-beta-hydroxyst
Research area
Cancer; Metabolism; Neuroscience; Signal transduction
Target protein
HSD17B1
