Homeodomain-interacting protein kinase 3

BT-AP09897

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized peptide derived from human protein . at AA range: 770-850

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

-20°C for 1 year

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors.,PTM:Autophosphorylated, but autophosphorylation is not required for Catalytic activity.,PTM:May be sumoylated.,Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.,Contains 1 protein kinase domain.,subunit:Interacts with Nkx1-2. Interacts with FAS and DAXX. Probably part of a complex consisting of HIPK3, FAS and FADD. Interacts with and stabilizes ligand-bound androgen receptor (AR) (By similarity). Interacts with UBL1/SUMO-1.,tissue specificity:Overexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at lower levels in placenta, pancreas, brain, spleen, prostate, thymus, testis, small intestine, colon and leukocytes. Not found in liver and lung.,

Human:;Mouse:;Rat:;

Human: 10114

Homeodomain-interacting protein kinase 3 ;EC 2.7.11.1;Androgen receptor-interacting nuclear protein kinase;ANPK;Fas-interacting serine/threonine-protein kinase;FIST;Homolog of protein kinase

Cell biology; Epigenetics and nuclear signaling; Signal transduction

HIPK3