IκB-alpha Polyclonal Antibody

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Blood coagulation
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Cancer
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Cell biology
Signal transduction
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Epigenetics and nuclear signaling
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Home > Product > Antibody > IκB-alpha Polyclonal Antibody

IκB-alpha Polyclonal Antibody

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity:Human, Mouse, Rat

Applications: WB, IHC-p, IF, ICC, ELISA

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC-p, IF, ICC, ELISA

Product overview

Full product name

NF-kappa-B inhibitor alpha

Code

BT-AP10544

Host

Rabbit

Isotype

IgG

Size

20ul,50ul,100ul

Clonality

Polyclonal

Immunogen

The antiserum was produced against synthesized peptide derived from human IkappaB-alpha. AA range:9-58

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

-20°C for 1 year

Background

This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.

Uniprot accession

Human:;Mouse:;Rat:;

Molecular weight

35609

Gene ID

Human: 4792; Mouse: 18035; Rat: 25493

Synonyms

NF-kappa-B inhibitor alpha; NFKBIA; IKBA; MAD3; NFKBI; NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3

Research area

Cancer; Epigenetics and nuclear signaling; Immunology; Signal transduction

Target protein

NFKBIA

Recommended dilution

Application	Dilution
WB	1: 500 - 1: 2000
IHC-p	1: 100 - 1: 300
IF	1: 200 - 1: 1000
ICC	1: 200 - 1: 1000
ELISA	1: 10000

Images

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using IkappaB-alpha Antibody. The picture on the right is blocked with the synthesized peptide.

Western Blot analysis of various cells using IκB-α Polyclonal Antibody

Western blot analysis of lysates from HUVEC cells, treated with TNF-α 20ng/ml 30', using IkappaB-alpha Antibody. The lane on the right is blocked with the synthesized peptide.

Protocols

> Protocol Booklet

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Datasheet

Product size

Price

20ul

$108.00
50ul

$180.00
100ul

$275.00

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Lead time: Within one week

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