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Home > Product > Antibody > LATS1/2(Phospho Thr1079/1041) Polyclonal Antibody

LATS1/2(Phospho Thr1079/1041) Polyclonal Antibody

LATS1/2(Phospho Thr1079/1041) Polyclonal Antibody

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity:Human, Mouse

Applications: IHC-p, IF, ELISA

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse

Applications: IHC-p, IF, ELISA

Product overview

Full product name

Serine/threonine-protein kinase LATS1/2

Code

BT-AP10852

Host

Rabbit

Isotype

IgG

Size

20ul,50ul,100ul

Clonality

Polyclonal

Immunogen

The antiserum was produced against synthesized peptide derived from human LATS1/2 around the phosphorylation site of Thr1079/1041. AA range:1041-1090

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

-20°C for 1 year

Background

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatmen

Uniprot accession

Molecular weight

126870;120194

Gene ID

Human: 9113/26524; Mouse: 16798/50523

Synonyms

Serine/threonine-protein kinase LATS1/2; LATS1; WARTS; Serine/threonine-protein kinase LATS1; Large tumor suppressor homolog 1; WARTS protein kinase; h-warts; LATS2; KPM; Serine/threonine-protein kinase LATS2; Kinase phosphorylated during mitosis protein; Large tumor suppressor ho

Research area

Cancer; Cell biology

Target protein

LATS1

Recommended dilution

Application Dilution
IHC-p 1: 100 - 1: 300
ELISA 1: 20000

Images

Immunohistochemistry analysis of paraffin-embedded human brain, using LATS1/2 (Phospho-Thr1079/1041) Antibody. The picture on the right is blocked with the phospho peptide.

Protocols

Customer reviews and Q&As

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Product size

Price

  • 20ul

    $108.00

  • 50ul

    $180.00

  • 100ul

    $275.00

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Lead time: Within one week

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