Methyl-CpG-binding protein 2

BT-AP11209

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthetic Peptide of MeCP2

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

-20°C for 1 year

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isofor

Human:;Mouse:;Rat:;

Human: 4204; Mouse: 17257; Rat: 29386

Methyl-CpG-binding protein 2; Methyl-CpG-binding protein 2; MeCp-2 protein; MeCp2

Epigenetics and nuclear signaling; Neuroscience

MECP2