MEK2 Rabbit Polyclonal Antibody

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Home > Product > Antibody > MEK2 Rabbit Polyclonal Antibody

MEK2 Rabbit Polyclonal Antibody

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity:Human

Applications: WB, IHC-p, IF

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Applications: WB, IHC-p, IF

Product overview

Full product name

Dual specificity mitogen-activated protein kinase kinase 2

Code

BT-AP11273

Host

Rabbit

Isotype

IgG

Size

20ul,50ul,100ul

Clonality

Polyclonal

Immunogen

Recombinant Protein of MEK2

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

-20°C for 1 year

Background

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.

Uniprot accession

Human:;Mouse:;

Gene ID

Human: 5605

Synonyms

Dual specificity mitogen-activated protein kinase kinase 2 ;MAP kinase kinase 2;MAPKK 2;EC 2.7.12.2;ERK activator kinase 2;MAPK/ERK kinase 2;MEK 2; Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK 2; EC 2.7.12.2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2

Research area

Signal transduction; Cancer

Target protein

MAP2K2

Recommended dilution

Application	Dilution
WB	1: 500 - 1: 2000
IHC-p	1: 50 - 1: 300
ELISA	1: 20000

Images

Immunohistochemical analysis of paraffin-embedded Human Colon Carcinoma Tissue using MEK2 Rabbit pAb diluted at 1:200

Western blot analysis of 1) Hela Cell Lysate, 2)293t Cell Lysate using MEK2 Rabbit pAb diluted at 1:2000.

Protocols

> Protocol Booklet

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Datasheet

Product size

Price

20ul

$108.00
50ul

$180.00
100ul

$275.00

Add to Cart

Lead time: Within one week

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