Histone-lysine N-methyltransferase MLL

BT-AP11380

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthetic peptide from human protein at AA range: 3850-3900

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.

Human:;Mouse:;

Human: 4297; Mouse: 214162

Histone-lysine N-methyltransferase MLL ;EC 2.1.1.43;ALL-1;CXXC-type zinc finger protein 7;Lysine N-methyltransferase 2A;KMT2A;Trithorax-like protein;Zinc finger protein HRX [Cleaved into:; Histone-lysine N-methyltransferase MLL; EC 2.1.1.43; ALL-1; CXXC-type zinc finger protein 7; Lysine N-methyltransferase 2A; KMT2A; Trithorax-like protein; Zinc finger protein HRX; MLL cleavage product N320; N-terminal cleavage product of 320 kDa; p320; MLL cleavage product C180; C-terminal cleavage product of 180 kDa; p180;

Cancer; Epigenetics and nuclear signaling

MLL