Cardiotrophin-like cytokine factor 1

BT-AP11932

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthetic peptide from human protein at AA range: 171-220

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encodin

Human:;Mouse:;

Human: 23529; Mouse: 56708

Cardiotrophin-like cytokine factor 1 ;B-cell-stimulating factor 3;BSF-3;Novel neurotrophin-1;NNT-1; Cardiotrophin-like cytokine factor 1; B-cell-stimulating factor 3; BSF-3; Novel neurotrophin-1; NNT-1

Immunology

CLCF1