Full product name
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
Code
BT-AP12644
Host
Rabbit
Isotype
IgG
Size
100ul,50ul,20ul
Clonality
Polyclonal
Immunogen
Synthesized peptide derived from part region of human protein
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Storage
-20°C for 1 year
Background
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.
Uniprot accession
Gene ID
Human: 5286
Synonyms
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha ;PI3K-C2-alpha;PtdIns-3-kinase C2 subunit alpha;EC 2.7.1.154;Phosphoinositide 3-kinase-C2-alpha
Research area
Immunology; Signal transduction
Target protein
PIK3C2A
