Full product name
Eukaryotic translation initiation factor 2-alpha kinase 3
Code
BT-AP12928
Host
Rabbit
Isotype
IgG
Size
20ul,50ul,100ul
Clonality
Polyclonal
Immunogen
Synthesized peptide derived from human PEK/PERK Polyclonal
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage
-20°C for 1 year
Background
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
Uniprot accession
Gene ID
Human: 9451; Mouse: 0; Rat: 29702
Synonyms
Eukaryotic translation initiation factor 2-alpha kinase 3 ;EC 2.7.11.1;PRKR-like endoplasmic reticulum kinase;Pancreatic eIF2-alpha kinase;HsPEK; Eukaryotic translation initiation factor 2-alpha kinase 3; EC 2.7.11.1; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK
Research area
Epigenetics and nuclear signaling; Metabolism
Target protein
EIF2AK3
