PLB(Phospho Ser16/T17) Polyclonal Antibody

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Blood coagulation
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Home > Product > Antibody > PLB(Phospho Ser16/T17) Polyclonal Antibody

PLB(Phospho Ser16/T17) Polyclonal Antibody

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity:Human, Mouse, Rat

Applications: IF, ICC, ELISA

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IF, ICC, ELISA

Product overview

Full product name

Cardiac phospholamban

Code

BT-AP13150

Host

Rabbit

Isotype

IgG

Size

20ul,50ul,100ul

Clonality

Polyclonal

Immunogen

The antiserum was produced against synthesized peptide derived from human PLB around the phosphorylation site of Ser16 and Thr17. AA range:1-50

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

-20°C for 1 year

Background

The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.

Uniprot accession

Human:;Mouse:;Rat:;

Molecular weight

6109

Gene ID

Human: 5350; Mouse: 18821; Rat: 64672

Synonyms

Cardiac phospholamban; PLN; PLB; Cardiac phospholamban; PLB

Research area

Cardiovascular; Signal transduction; Tags & cell markers; Metabolism

Target protein

PLN

Recommended dilution

Application	Dilution
IF	1: 200 - 1: 1000
ICC	1: 200 - 1: 1000
ELISA	1: 10000

Images

Immunofluorescence analysis of HUVEC cells, using PLB (Phospho-Ser16+Thr17) Antibody. The picture on the right is blocked with the phospho peptide.

Protocols

> Protocol Booklet

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Datasheet

Product size

Price

20ul

$108.00
50ul

$180.00
100ul

$275.00

Add to Cart

Lead time: Within one week

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