Rap guanine nucleotide exchange factor 4

BT-AP13915

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized peptide derived from human protein . at AA range: 240-320

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

-20°C for 1 year

The DEP domain is involved in membrane localization independent from regulation by cAMP.,The N-terminal nucleotide phosphate binding region cAMP 1 has a much lower affinity for cAMP as compared to cAMP 2.,Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.,Contains 1 DEP domain.,Contains 1 N-terminal Ras-GEF domain.,Contains 1 Ras-GEF domain.,Contains 2 cyclic nucleotide-binding domains.,subunit:Interacts with RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A.,tissue specificity:Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels.,

Human:;Mouse:;Rat:;

Human: 11069

Rap guanine nucleotide exchange factor 4 ;Exchange factor directly activated by cAMP 2;Exchange protein directly activated by cAMP 2;EPAC 2;cAMP-regulated guanine nucleotide exchange factor II

Signal transduction

RAPGEF4